Well, the mere fact that you are dealing with: Minerals, Vitamins, Oils and the like. Some, are water soluble, others solvent soluble, hydrophilic, hydrophobic, differing atomic masses and to top it all off, different ion charges(some negative and others positively charged), hence attracted to different other compounds.
All, leading to a Big Challenge!
If we take a mineral like magnesium, if the liposomes are not constructed well, or the not the right size, the magnesium, will come away and form a sediment on the bottom of the bottle. At this point, even if you shake the bottle, it won't insert back into liposome.
Our challenge was to combine 23 great ingredients into a liquid liposome (tiny-lipid-bubble), but we achieved it.